TwoSampleMR 0.4.8

Two sample Mendelian randomisation is a technique that makes causal inference about an exposure on an outcome using only summary statistics from a GWAS. This means you obtain SNPs (the instruments) that are robustly associated with your exposure, obtain a set of GWAS summary associations for the outcome you are interested, extract the instrument SNPs from the outcome GWAS, and by contrasting the effect sizes of the SNPs on the exposure with the effect sizes of the SNPs on the outcome one can estimate the causal effect.

This version of TwoSampleMR comes with MRInstruments 0.3.2 to provide more instruments to TwoSampleMR.

Accessing the software

To load the module:

$ module load TwoSampleMR/0.4.8-iomkl-2018a-R-3.5.0

To load the libraries into an R session, issue the following commands into the R interpreter with the module loaded:

> library(TwoSampleMR)
> library(MRInstruments)

Accessing Previous Versions

Wherever possible, previous versions of this application will be retained for continuity, especially for research projects that require a consistent version of the software throughout the project. Such versions, however, may be unsupported by IT Services or the applications vendor, and may be withdrawn at short or no notice if they can no longer run on the cluster - for example, essential operating system upgrades may be incompatible with old versions.

At present there are no previous versions of this application on the BlueBEAR service.

Known Problems & Limitations


Other Information

The Support Level for this application is An.

Visit the TwoSampleMR Github repository and MRInstruments Github repository for more information regarding this application.

Last modified: 31 May 2018